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A Combo offer to deal with Melanoma: Latest Development with Immune Checkpoint Inhibitors


Modern Science has experienced huge breakthroughs over the last decades, one of the major ones being the discovery of immune checkpoints and their inhibitors. The checkpoint inhibitors revolutionized the stagnant field of cancer biology and were responsible for the rise of cancer immunotherapies. Immunotherapies command the immune system to destroy tumors by using antibodies against specific immunosuppressive surface receptors. Programmed cell death protein-1 (PD-1) is one such receptor expressed on T cells that interacts with programmed cell death ligand-1 (PD-L1) present on tumor cells, which leads to inactivation and subsequent anergy (absence of normal immune response) of T cells. Cytotoxic T lymphocyte-associated protein-4 (CTLA-4) is another receptor that is constitutively expressed on regulatory T cells and enhances its role by inhibiting the functions of other T cells and antigen-presenting cells, hence helping tumor growth. Monoclonal antibody treatments targeting these protein receptors are now widely used in clinics and have helpedā€¦

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