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A Song of Marrow and Microbes


Stem cells! Iron! Macrophages! Red blood cells! Butyrate! Gut microbiota!
No, we are not just blurting out random terms (stick with us till the end to read the full story). These keywords summarize a study by Zhang and colleagues that was published in Cell Stem Cell earlier this month. However, summarizing the work in a single sentence would take out the fun from this fascinating study, and also leave you scratching your head. So instead, I present to you, the song of Marrow & Microbes!

Hematopoietic Stem Cells (HSCs) are the stem cells that give rise to everything that falls under the purview of “Blood cells”. They sit at the top of the pyramid and differentiate into common myeloid progenitors (producing Red Blood cells, platelets, mast cells, and granulocytes) and lymphoid progenitors (producing B, T cells & Natural Killer cells). HSCs station in the bone marrow throughout our life, and…

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