Design a site like this with
Get started

Shifting Paradigms: T Cells, FlipFlops, and Reversed T Cells


You must have come across the fundamental concepts of T cell development during your immunology class. Briefly, in the thymus, T cells expressing both CD4 and CD8 coreceptors interact with MHC molecules on thymic epithelial cells to make lineage fate decisions. CD4+ cells interact with MHCII and are called T helper cells while CD8+ cells interact with MHCI and are called cytotoxic T cells. Debates over the nitty-gritty of how this selection takes place have consisted of two main theories: “Strength of Signal model” and “Kinetic Signaling model”.

The “Strength of Signal model”, as the name suggests, focuses on the strength of the signal originating from T cell receptor (TCR) – coreceptor interactions with MHC molecules. A strong CD4-TCR signal gives rise to helper lineage while a weak CD8-TCR signal gives rise to cytotoxic lineage. According to the “Kinetic Signaling model”, the lineage decisions arise from the duration of the…

View original post 1,027 more words

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

Website Powered by

Up ↑

%d bloggers like this: